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What is Percocet?

Percocet is a combination of two drugs that are acetaminophen and oxycodone. Oxycodone is an opioid, whereas acetaminophen is non-opioid pain medication. However, an opioid is sometimes called a narcotic. 

Moreover, acetaminophen is less potent that increases the effects of oxycodone to relieve the pain.

Percocet helps in treating moderate to severe pain.

Due to the risk of misuse, overdose, and addiction, Percocet is only available on the prescription of a doctor when the other non-opioid medication is not able to provide adequate pain relief. 

Additionally, Percocet may also be used for the purposes that are not listed here.

How does Percocet work?

Percocet is an opioid whereas opioid works by binding with opioid receptors. They are found in the body, especially in the brain, including the spinal cord and gastrointestinal tract. However, It works by attaching with opioid receptors and reduces the pain messages transmission coming from the brain. That is how it reduces the pain rapidly.

Percocet Onset of Action

After swallowing the Percocet, it starts absorbing in your body and begins working in 15 to 30 minutes to relieve pain. However, Percocet reaches its peak effects within 1 hour and continues to work for 3 to 6 hours. 

Percocet Dosage

Use the lowest possible dosage for the shorter duration with individual patient goals.

Additionally, the dosage of Percocet initiates regimen for each of the individuals on account of:

The severity of the pain;

Patients response towards drug;

prior analgesic treatment experience, and 

risk factors for abuse, addiction, and misuse.

At the starting of the treatment, monitor closely for respiratory depression, especially for 24 to 72 hours.

However, adjust the dosage accordingly.

Initial dosage for adults: Tablets 2.5 mg/325 mg; 1 or 2 tablets every 6 hours or as needed for pain. Do not exceed the dose of more than 4 grams a day.

Further Information

Always ask your health care provider before taking any medication, especially opioid medicines, to ensure all the information displayed here applies to your circumstances.

Side effects of Percocet

Along with the needed impact of Percocet, it may cause unwanted effects. Although not all of them require medical attention, they will vanish in some time. If they are getting worse, consult your doctor immediately.

Some of the common side effects of Percocet are:

  • fever
  • headache
  • itching, skin rash (unusual)
  • light-colored stools
  • loss of appetite
  • Nausea
  • Black, tarry stools
  • chills
  • dark urine
  • dizziness
  • stomach pain
  • unpleasant breath odor
  • unusual tiredness 
  • weakness
  • vomiting of blood (unusual)
  • yellow eyes or skin (rare)

You can report your symptoms to the FDA if they are getting worse, however, call 911 for immediate medical attention.

Percocet Addiction or Overdose

Opioid medication has a high risk of addiction, abuse due to overdose. Taking such opioid medicines without prescription or abruptly also leads to overdose and addiction. 

Sometimes, a patient tries to take an overdose to reduce the pain at once, which tends to have fatal side effects. Doing so can be life-threatening and can cause severe respiratory distress. 

Moreover, the treatment for opioid addiction/overdose is available that includes detox, therapy, maintenance medications, and aftercare. 

Use in pregnancy?

It is necessary for the patient to tell the doctor if she is pregnant before starting the

treatment. The use of Percocet in trimester would cause respiratory depression or sedation

in neonates. However, If, in any case, a woman is using Percocet (in the trimester), the doctor should monitor the neonates for a sign of sleeping more than usual, breathing difficulties, or


Moreover, it is useful if you avoid using such opioid medicines during pregnancy or breastfeeding. It will lead to side effects in the newborn, or may also develop an addiction.


There are 20 disease interactions of Percocet; some of them are:

  • alcoholism
  • liver disease
  • impaired GI motility
  • infectious diarrhea
  • biliary spasm
  • hypothyroidism
  • renal dysfunction
  • seizure disorders
  • respiratory depression

Ask your doctor for further information about drug interaction. However, you can tell your doctor if you have any disease that might interact with it. Doing so, you can decrease the risk of side effects.

Some of the drug interactions of Percocet are:

  • Aspirin
  • ibuprofen 
  • metformin
  • methadone
  • Norco
  • Suboxone
  • Tramadol
  • Valium
  • Xanax
  • Gabapentin
  • Ambien

However, this is not a whole list of drug interactions, and others may also interact.


Percocet is an effective medication, along with the needed effects it causes unwanted

withdrawals if used abruptly. Use the drug by following proper instructions or also ask your doctor each time you get a refill.

The use of opioids without prescription is illegal, as well as fatal for a person or surroundings.

Moreover, the risk of Percocet in pregnancy is high; tell your doctor if you are pregnant. 

Do not use the medication or if you are allergic to it or have a Glaucoma or severe head

injury. Tell your physicist before the treatment if you have any previous condition that might interact with Percocet.